Effect of diosmetin on young rats with high-fat diet-induced non-alcoholic fatty liver disease
نویسندگان
چکیده

 Purpose: To determine the effect of diosmetin on young, non-alcoholic fatty liver disease (NAFLD) rats.
 Methods: Five groups SD rats were used: control group, high-fat diet low-dose medium-dose and high-dose each with 10 rats. After 3 months, interleukin 6 (IL-6), IL-1β) TNF-α) assayed. Protein expressions p-AMPKα, CPT-1 PPAR-α, AMPKα, SREBP-1c FAS assayed.
 Results: In levels PPAR-α lower than corresponding values, while dose-dependently higher in all NAFLD group (p < 0.05). There group. Serum IL-6, IL-1β TNF-α raised, relative to values 0.05).
 Conclusion: Diosmetin alleviates lesions induced by diet, slows down cell apoptosis, inhibits inflammation via activation AMPK pathway. Thus, has potentials for use repair hepatic damage diet.
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ژورنال
عنوان ژورنال: Tropical Journal of Pharmaceutical Research
سال: 2022
ISSN: ['1596-5996', '1596-9827']
DOI: https://doi.org/10.4314/tjpr.v20i2.14